Chemistry Events

See a list of this year’s seminar speakers, along with summaries of past seminars, on the Chemistry Department Seminars page.

Feb 15

Chemistry Department Seminar: Anna Brezny '13 entitled

"The Role of Off-Cycle Species in Rhodium-Catalyzed Styrene Hydroformylation Using High-Pressure NMR Spectroscopy".Official/Unofficial Story

Friday, February 15th, 2019
3:30 – 4:30 pm / Old Music Hall 103

Anna Brezny '13 (Feb.15, 2019)

 

 

 

Hydroformylation of alkenes for the synthesis of aldehydes is one of the largest scale homogenously catalyzed reactions in chemical industry. The widespread use of this method depends on our ability to control both the regio- and enantioselectivity of the reaction. While it has been empirically determined that the 3,4-bis(diazaphospholane) (BDP) class of ligands exhibits useful selectivities and rates in AHF, the origins of selectivity remain unclear.

The Wisconsin High-Pressure NMR Reactor (WiHP-NMRR) enables observation of catalyst speciation under realistic reaction conditions, which has revealed the importance of CO pressure on the resting state. Additionally, this apparatus has enabled non-catalytic single-turnover experiments – a powerful strategy for detailed kinetic analysis of individual mechanistic steps. Specifically, we have studied the rates of formation, isomerization, and hydrogenolysis of acyl intermediates. These results greatly expand our understanding of the highly selective BDP ligands in asymmetric hydroformylation.

Sponsored by Chemistry. Contact: Tami Little, x5769