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Joe Chihade

Joe Chihade

Introduction

My research interests are in the broad areas of protein-RNA interactions and RNA structure. These areas lie at the intersection of biology and chemistry, and encompass wide variety of scientific perspectives. These range from the "biological" questions of which proteins interact with particular RNAs, what the consequences of these interactions are to the living cell, and how particular interactions evolved, to the more "chemical" questions of how a specific functional group influences a macromolecular interaction or changes the structure of a macromolecule, and how a simple chemical reagent can be used to elucidate biological function.

For several years research in the lab has been focused on characterizing substrate recognition of alanyl-tRNA synthetases which aminoacylate the highly unusual tRNAs found in animal mitochondria. New projects involve evaluating aminoacyl-tRNA synthetases from parasitic worms as potential drug targets.

Education & Professional History

Oberlin College, BA; Columbia University, MA, PhD.; Post-doctoral work at M.I.T. and the Scripps Research Institute

At Carleton since 2003.

Highlights & Recent Activity

Biochemical Characterization of Pathogenic Mutations in Human Mitochondrial tRNAAla And Alanyl-tRNA Synthetase, presented at theĀ American Society for Biochemistry and Molecular Biology annual meeting, San Diego, CA, April, 2012

A Streamlined Molecular Biology Module for Undergraduate Biochemistry Labs. Gregory W. Muth, Joseph Chihade. Biochemistry and Molecular Biology Education, 36, 209 (2008).

Pre-transfer Editing by Class II Escherichia coli Prolyl-tRNA Synthetases: Role of Aminoacylation Active Site in "Selective Release" of Noncognate Amino Acids. Sanchita Hati, Brigitte Ziervogel, Julius SternJohn, Fai-Chu Wong, Maria C. Nagan, Abbey E. Rosen, Paul G. Siliciano, Joseph Chihade and Karin Musier-Forsyth, J. Biol. Chem., 281, 27862 (2006).

Organizations & Scholarly Affiliations

American Chemical Society

American Society for Biochemistry and Molecular Biology

RNA Society

Council on Undergraduate Research

Profile updated August 11, 2017

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